Structurally well-defined copolymers of poly(ethylene glycol) and low molecular weight linear polyethylenimine as vectors for gene delivery.
نویسندگان
چکیده
Structurally well-defined ABA triblock copolymers with low molecular weight linear polyethylenimine (PEI) as A block and poly(ethylene glycol) (PEG) as B block have been prepared and used for gene delivery. PEI–PEG–PEI 2100–3400–2100 can effectively condense DNA, giving small-sized polyplexes (b100 nm) with reduced zeta-potentials (b10 mV). Initial experiments show that these polyplexes have a better transfection efficiency and a decreased cytotoxicity compared to polyplexes based on low molecular weight linear PEI polymers.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of controlled release : official journal of the Controlled Release Society
دوره 101 1-3 شماره
صفحات -
تاریخ انتشار 2005